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Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex

被引：50
作者：
Minelli, A
Edwards, RH
Manzoni, T
Conti, F
机构：
[1] Univ Ancona, Ist Fisiol Umana, I-60020 Ancona, Italy
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
来源：
DEVELOPMENTAL BRAIN RESEARCH | 2003年 / 140卷 / 02期
关键词：
glutamate; glutamate transporter; vesicle; neocortex; callosal connection; associative connection; development;
D O I：
10.1016/S0165-3806(02)00617-X
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The expression of the vesicular glutamate transporter VGLUT1 in the rat neocortex was studied during postnatal development using immunocytochemistry and Western blotting. At all ages, VGLUT immunoreactivity is localized to puncta that coexpress the presynaptic marker synaptophysin. VGLUT1 immunoreactivity is faint at birth, increases in the subplate during the first postnatal week, invades the supragranular layers in the second week and reaches the adult pattern at P20-P30. Its spatial and temporal maturation patterns suggest that VGLUT1 may be the vesicular transporter in developing corticocortical connections. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：309 / 314
页数：6
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