Diffuse large B-cell lymphoma: a heterogeneous group of non-Hodgkin lymphomas comprising several distinct clinicopathological entities

被引：81

作者：

De Paepe, P.

De Wolf-Peeters, C.

机构：

[1] Catholic Univ Louvain, Dept Pathol, Div Morphol & Mol Pathol, B-3000 Louvain, Belgium

[2] AZ St Jan AV, Dept Pathol, B-8000 Brugge, Belgium

来源：

LEUKEMIA | 2007年 / 21卷 / 01期

关键词：

DLBCL; classification; morphology; microarray; immunohistochemistry;

D O I：

10.1038/sj.leu.2404449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) as defined by the World Health Organization (WHO) classification is clinically, morphologically and genetically a heterogeneous group of malignant proliferations of large lymphoid B cells. Over the last 6 years, several studies have been published improving our understanding of these lymphomas. These studies analyzed DLBCL by their gene expression profile, provided further information on some of the variants of DLBCL listed in the WHO classification and stressed the impact of the site of origin of these tumors. This review summarizes these recent data and explores their impact on the recognition of new clinicopathological lymphoma entities.

引用

页码：37 / 43

页数：7

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