Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: Comparison with chemotherapeutic agents

被引：9

作者：

ElAttar, TMA ^{[1
]}

Virji, AS ^{[1
]}

机构：

[1] UNIV MISSOURI, SCH MED, HORMONE RES LAB, KANSAS CITY, MO 64108 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1997年 / 56卷 / 06期

关键词：

D O I：

10.1016/S0952-3278(97)90600-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four cyclopentenone prostaglandins (CPPGs) and PGE(2) caused significant dose-dependent inhibition in growth of human oral squamous carcinoma cells (SCC-15). The rank order of their potency was PGJ(2)>PGA(1)>16, 16-dimethyl PGA(1)>PGA(2)>PGE(2). In a follow-up experiment it was found that the mean per cent inhibition in cell growth by PGJ(2) and Delta(12)-PGJ(2) at 10(-5) M was 61.22 and 63.81, while that of 5-fluorouracil and methotrexate was 36.67 and 38.86, respectively. Delta(12)-PGJ(2) and PGJ(2) induced significant dose-dependent inhibition in nuclear DNA synthesis (i.e. cell proliferation). Combining vitamin E succinate with lower concentrations of CPPGs enhanced significantly their inhibitory effect on nuclear DNA synthesis of cancer cells.

引用

页码：461 / 465

页数：5

共 32 条

[11] Hughes-Fulford M, 1985, Adv Prostaglandin Thromboxane Leukot Res, V15, P401
[12] ISHIOKA C, 1988, CANCER RES, V48, P2813
[13] KATO T, 1986, CANCER RES, V46, P3538
[14] 9-DEOXY-DELTA-9,DELTA-12-13,14-DIHYDROPROSTAGLANDIN-D2, A METABOLITE OF PROSTAGLANDIN-D2 FORMED IN HUMAN-PLASMA
KIKAWA, Y
NARUMIYA, S
FUKUSHIMA, M
WAKATSUKA, H
HAYAISHI, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05): : 1317 - 1321
[15] ADJUVANT EFFECTS OF ANTINEOPLASTIC PROSTAGLANDINS TO CISPLATIN IN NUDE-MICE BEARING HUMAN OVARIAN-CANCER CELLS
KIKUCHI, Y
KITA, T
MIYAUCHI, M
HIRATA, J
SASA, H
NAGATA, I
FUKUSHIMA, M
[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1992, 118 (06) : 453 - 457
[16] PROSTAGLANDIN-A2 AND DELTA-12-PROSTAGLANDIN-J2 INDUCE APOPTOSIS IN L1210 CELLS
KIM, IK
LEE, JH
SOHN, HW
KIM, HS
KIM, SH
[J]. FEBS LETTERS, 1993, 321 (2-3) : 209 - 214
[17] KLINE K, 1991, VITAMINS AND MINERALS IN THE PREVENTION AND TREATMENT OF CANCER, P189
[18] KOIZUMI T, 1992, BIOCHEM PHARMACOL, V44, P1597
[19] MODTAHEDI H, 1993, INT J ONCOL, V3, P237
[20] NARUMIYA S, 1987, J PHARMACOL EXP THER, V242, P306

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