Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: Comparison with chemotherapeutic agents

被引：9

作者：

ElAttar, TMA ^{[1
]}

Virji, AS ^{[1
]}

机构：

[1] UNIV MISSOURI, SCH MED, HORMONE RES LAB, KANSAS CITY, MO 64108 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1997年 / 56卷 / 06期

关键词：

D O I：

10.1016/S0952-3278(97)90600-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four cyclopentenone prostaglandins (CPPGs) and PGE(2) caused significant dose-dependent inhibition in growth of human oral squamous carcinoma cells (SCC-15). The rank order of their potency was PGJ(2)>PGA(1)>16, 16-dimethyl PGA(1)>PGA(2)>PGE(2). In a follow-up experiment it was found that the mean per cent inhibition in cell growth by PGJ(2) and Delta(12)-PGJ(2) at 10(-5) M was 61.22 and 63.81, while that of 5-fluorouracil and methotrexate was 36.67 and 38.86, respectively. Delta(12)-PGJ(2) and PGJ(2) induced significant dose-dependent inhibition in nuclear DNA synthesis (i.e. cell proliferation). Combining vitamin E succinate with lower concentrations of CPPGs enhanced significantly their inhibitory effect on nuclear DNA synthesis of cancer cells.

引用

页码：461 / 465

页数：5