Organocatalytic Aziridine Synthesis Using F+ Salts

被引：30

作者：

Bew, Sean P. ^{[1
]}

Fairhurst, Shirley A. ^{[2
]}

Hughes, David L. ^{[1
]}

Legentil, Laurent ^{[1
]}

Liddle, John ^{[3
]}

Pesce, Paolo ^{[1
]}

Nigudkar, Sanket ^{[1
]}

Wilson, Martin A. ^{[1
]}

机构：

[1] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England

[2] John Innes Ctr, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England

[3] GlaxoSmithKline Res & Dev Ltd, Dept Med Chem, Med Res Ctr, Stevenage, Herts, England

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

基金：

英国工程与自然科学研究理事会;

关键词：

CATALYTIC ASYMMETRIC AZIRIDINATION; FLUORINATING AGENTS; DIASTEREOSELECTIVE SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; ESTERS; IMINES; DERIVATIVES; AMINATION;

D O I：

10.1021/ol901784m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes a unique application of the fluoronium cation (F+) as an organocatalyst for mediating the reaction between N-substituted imines and ethyl diazoacetate affording excellent yields of N-substituted aziridines.

引用

页码：4552 / 4555

页数：4

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