Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

被引：289

作者：

Scott, Lauren E. ^{[1
]}

Orvig, Chris ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Med Inorgan Chem Grp, Vancouver, BC V6T 1Z1, Canada

来源：

CHEMICAL REVIEWS | 2009年 / 109卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

AMYLOID-BETA-PEPTIDE; BLOOD-BRAIN-BARRIER; PYRIDOXAL ISONICOTINOYL HYDRAZONE; IRON-CHELATION-THERAPY; TRANSGENIC MOUSE MODEL; ALZHEIMER A-BETA; OXIDASE INHIBITOR DRUGS; CENTRAL-NERVOUS-SYSTEM; HYDROGEN-PEROXIDE; WILSONS-DISEASE;

D O I：

10.1021/cr9000176

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate medicinal inorganic chemistry approaches to passivation and removal of abberant metal ions in disease. The study addressed the future of the design and utility of metal chelating drugs for disease therapy and focused on the development of therapeutics for amyotrophic lateral sclerosis (ALS), transmissible spongiform encephalopathies (TSEs), cancer, and malaria. It was revealed that the most common medicinal application of metal chelators was in the treatment of metal overload conditions. The introduced metal-binding therapeutic needed to participate in a series of ligand exchange reactions to form the new desired complex before achieving metal ion repartitioning or removal.

引用

页码：4885 / 4910

页数：26

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