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Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection

被引：51
作者：
Fleming, HE
Paige, CJ
机构：
[1] Univ Toronto, Princess Margaret Hosp, Ontario Canc Inst,Dept Immunol, Hlth Network, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Princess Margaret Hosp, Ontario Canc Inst,Dept Med Biophys, Hlth Network, Toronto, ON M5G 2M9, Canada
来源：
SEMINARS IN IMMUNOLOGY | 2002年 / 14卷 / 06期
基金：
加拿大健康研究院;
关键词：
interleukin-7; pre-BCR; development; ERK; MAPK; microenvironment;
D O I：
10.1016/S1044532302000775
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hematopoiesis is regulated by a variety of signals that either originate within a developing cell or are supplied by the surrounding environment in secreted- or contact-dependent forms. This review discusses the effects of one secreted factor, interleukin-7, on the development of B lymphocytes. We describe a molecular mechanism for a crucial checkpoint during B lineage maturation, based on the integration of signals mediated by the pre-B cell receptor, the interleukin-7 receptor, and the environment in which these signals are received.
引用
收藏
页码：423 / 430
页数：8
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