High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems

被引：44

作者：

Kogure, K ^{[1
]}

Hama, S ^{[1
]}

Manabe, S ^{[1
]}

Tokumura, A ^{[1
]}

Fukuzawa, K ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Dept Hlth Chem, Tokushima 7708505, Japan

来源：

CANCER LETTERS | 2002年 / 186卷 / 02期

基金：

日本学术振兴会;

关键词：

alpha-tocopheryl hemisuccinate; apoptosis; superoxide; reactive oxygen species; cancer cells;

D O I：

10.1016/S0304-3835(02)00344-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

alpha-Tocopheryl hemisuccinate (TS) has been reported to induce apoptosis in various cells, and to show higher toxicity to cancer cells than to normal cells. In this study, although TS induced apoptosis in both a mouse breast normal cell line NMuMG and a mouse breast cancer cell line C1271, the latter were more susceptible to TS. TS-induced apoptosis in C1271 was inhibited by superoxide dismutase, alpha-tocopherol and butylated hydroxyanisol. From these results, superoxide (O-2(-)) itself and reactive oxygen species derived from O-2(-) and/or free radicals are assumed to be associated with TS toxicity, and the high toxicity of TS to cancer cells is suggested to be due to failure of their antioxidative defense systems. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 156

页数：6

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