Lipid droplets and hepatitis C virus infection

被引：74

作者：

McLauchlan, John ^{[1
]}

机构：

[1] MRC, Virol Unit, Glasgow G11 5JR, Lanark, Scotland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 06期

基金：

英国医学研究理事会;

关键词：

Hepatitis C virus; HCV; Core protein; Steatosis; Virus infection; Virus assembly; LOW-DENSITY LIPOPROTEIN; SIGNAL PEPTIDE PEPTIDASE; NONSTRUCTURAL PROTEIN 5A; DIFFERENTIATION-RELATED PROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; RNA-CONTAINING PARTICLES; CORE PROTEIN; TRANSGENIC MICE; HEPATOCELLULAR-CARCINOMA; CELL-CULTURE;

D O I：

10.1016/j.bbalip.2008.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid droplets play an important part in the life cycle of hepatitis C virus and also are markets for steatosis, which is a common condition that arises during infection. These storage organelles are targeted by the viral core protein, which forms the capsid shell. Attachment of core to lipid droplets requires a C-terminal domain within the protein that is highly conserved between different virus isolates. In infected cells, the presence of core on lipid droplets creates loci that contain viral RNA and non-structural proteins involved in genome replication. Such locations may represent sites for initiating assembly and production of nascent virions. In addition to utilising lipid droplets as part the virus life cycle, hepatitis C virus induces their accumulation in infected hepatocytes. The mechanisms involved in this process are not understood but evidence from patient-based studies and model systems suggests the involvement of both viral and host factors. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：552 / 559

页数：8

共 122 条

[121] Origin of hepatic very-low-density lipoprotein triacylglycerol: The contribution of cellular phospholipid [J].