Synthesis of (+)-trixagol and its enantiomer, the terpenoid side chain of (-)-agelasine E

被引：16

作者：

Bakkestuen, AK ^{[1
]}

Gundersen, LL ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

TETRAHEDRON | 2003年 / 59卷 / 01期

关键词：

alkylation; antibacterials; natural products; sulfones; terpenoids;

D O I：

10.1016/S0040-4020(02)01455-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The naturally occurring gamma-cyclogeranylgeraniol called (+)-trixagol has been synthesised for the first time. Trixagol was readily available in five steps from (S)-2,2-dimethyl-6-methylene-1-cyclohexanemethanol. The enantiomer of trixagol, which equates to the terpenoid side chain of the naturally occurring 7,9-dialkylpurinium salt (-)-agelasine E, was prepared from the (R) enantiomer of the cyclohexanemethanol. Both trixagol enantiomers were moderately active against Mycobacterium tuberculosis. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：115 / 121

页数：7

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