Cytotoxic and antibacterial activity of 2-oxopurine derivatives

被引：60

作者：

Andresen, G

Gundersen, LL

Nissen-Meyer, J

Rise, F

Spilsberg, B

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

[2] Univ Oslo, Dept Biochem, N-0316 Oslo, Norway

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00803-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：567 / 569

页数：3

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