Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats

被引：73

作者：

Ra, SM

Hong, K

Jang, MH

Shin, MC

Lee, TH

Lim, BV

Kim, CJ ^{[1
]}

Kim, EH

Kim, KM

Kim, SS

机构：

[1] Kyung Hee Univ 1, Coll Med, Dept Physiol, Dongdaemoon Gu, Seoul 130701, South Korea

[2] Korea Univ, Res Inst Sports Sci, Seoul, South Korea

[3] Semyung Univ, Coll Oriental Med, Dept Meridianol, Jechon, South Korea

[4] Inje Univ, Coll Biomed Sci & Engn, Dept Occupat Therapy, Pusan, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 333卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

treadmill running; swimming; 5-bromo-2 '-deoxyuridine; naloxone; dentate gyrus; cell proliferation;

D O I：

10.1016/S0304-3940(02)01031-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of treadmill exercise and swimming on cell proliferation in the dentate gyrus and the involvement of opioid receptors were investigated via 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. Sprague-Dawley rats of the running groups were made to run on treadmill for 30 min each day, while those of the swimming groups were made to swim for 5 min each day over 3 consecutive days. In addition, intensity-dependency of the effects of running and swimming on cell proliferation was investigated. The present results demonstrate that both treadmill running and swimming increase the number of BrdU-labeled cells in the dentate gyrus and these increasing effects are more potent in light intensity and 5 min swimming groups. Treatment with naloxone increases cell proliferation in the dentate gyrus in all groups, although this increase is statistically insignificant. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：123 / 126

页数：4

共 19 条

[1] Deep water running: An effective non-weightbearing exercise for the maintenance of land-based running performance [J].