Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina

被引：267

作者：

Kubicek, Christian P. ^{[1
]}

Mikus, Marianna ^{[1
]}

Schuster, Andre ^{[1
]}

Schmoll, Monika ^{[1
]}

Seiboth, Bernhard ^{[1
]}

机构：

[1] TU Vienna, Inst Chem Engn, Res Area Gene Technol & Appl Biochem, A-1060 Vienna, Austria

来源：

BIOTECHNOLOGY FOR BIOFUELS | 2009年 / 2卷

基金：

奥地利科学基金会;

关键词：

CARBON CATABOLITE REPRESSION; ANAMORPH TRICHODERMA-REESEI; CELLOBIOHYDROLASE-II-GENE; CONIDIAL-BOUND CELLULASE; D-XYLOSE METABOLISM; ASPERGILLUS-NIDULANS; BETA-GLUCOSIDASE; G-PROTEIN; LACTOSE METABOLISM; D-GALACTOSE;

D O I：

10.1186/1754-6834-2-19

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hypocrea jecorina (= Trichoderma reesei) is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.

引用

页数：14

共 112 条

[1] ACEI of Trichoderma reesei is a repressor of cellulase and xylanase expression [J].

Aro, N ;

Ilmén, M ;

Saloheimo, A ;

Penttilä, M .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (01) :56-65

[2] ACEII, a novel transcriptional activator involved in regulation of cellulase and xylanase genes of Trichoderma reesei [J].

Aro, N ;

Saloheimo, A ;

Ilmén, M ;

Penttilä, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :24309-24314

[3] The potential of cellulases and cellulosomes for cellulosic waste management [J].

Bayer, Edward A. ;

Lamed, Raphael ;

Himmel, Michael E. .

CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (03) :237-245

[4] A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination [J].

Boase, NA ;

Kelly, JM .

MOLECULAR MICROBIOLOGY, 2004, 53 (03) :929-940

[5] DEPENDENCE OF LACTOSE METABOLISM UPON MUTAROTASE ENCODED IN THE GAL OPERON IN ESCHERICHIA-COLI [J].

BOUFFARD, GG ;

RUDD, KE ;

ADHYA, SL .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 244 (03) :269-278

[6] Regulation of activity of the transcription factor GATA-1 by acetylation [J].

Boyes, J ;

Byfield, P ;

Nakatani, Y ;

Ogryzko, V .

NATURE, 1998, 396 (6711) :594-598

[7] Interlocked feedback loops of the circadian clock of Neurospora crassa [J].

Brunner, Michael ;

Kaldi, Krisztina .

MOLECULAR MICROBIOLOGY, 2008, 68 (02) :255-262

[8]

Buchert J., 1998, Trichoderma and Gliocladium Enzymes, Biological Control and Commercial Applications, P343

[9]

CarleUrioste JC, 1997, J BIOL CHEM, V272, P10169, DOI 10.1074/jbc.272.15.10169

[10] Glucose repression in yeast [J].

Carlson, M .

CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (02) :202-207

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