What is Cooperativity?

被引：664

作者：

Hunter, Christopher A. ^{[1
]}

Anderson, Harry L. ^{[2
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Oxford, Dept Chem, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 41期

关键词：

allosteric cooperativity; chelate cooperativity; cooperative effects; self-assembly; supramolecular chemistry; SECONDARY INTERACTIONS; NUCLEATION-ELONGATION; STATISTICAL FACTORS; BINDING-ENERGY; PORPHYRIN; UREA; THERMODYNAMICS; MULTIVALENCY; CYCLODEXTRIN; MECHANISMS;

D O I：

10.1002/anie.200902490

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The lamprey holds the clue to the link between supramolecular self-assembly and allosteric ligand binding. Chelate cooperativity in self-assembled structures results in denaturation behavior that is indistinguishable from allosteric ligand binding. The chelate effect is the most common origin of positive cooperativity, yet its significance has been widely overlooked. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7488 / 7499

页数：12