Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology

被引:198
作者
Mou, ZL [1 ]
He, YK [1 ]
Dai, Y [1 ]
Liu, XF [1 ]
Li, JY [1 ]
机构
[1] Acad Sinica, Inst Genet, Beijing 100101, Peoples R China
关键词
D O I
10.1105/tpc.12.3.405
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An Arabidopsis mosaic deafh1 (mod1) mutant, which has premature cell death in multiple organs, was isolated, mod1 plants display multiple morphological phenotypes, including chlorotic and curly leaves, distorted siliques, premature senescence of primary inflorescences, reduced fertility, and semidwarfism. The phenotype of the mod1 mutant results from a single nuclear recessive mutation, and the MODI gene was isolated by using a map-based cloning approach. The MOD1 gene encodes an enoyl-acyl carrier protein (ACP) reductase, which is a subunit of the fatty acid synthase complex that catalyzes de novo synthesis of fatty acids. An amino acid substitution in the enoyl-ACP reductase of the mod1 mutant causes a marked decrease in its enzymatic activity, impairing fatty acid biosynthesis and decreasing the amount of total lipids in mod1 plants, These results demonstrate that a deficiency in fatty acid biosynthesis has pleiotropic effects on plant growth and development and causes premature cell death.
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页码:405 / 417
页数:13
相关论文
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