SR1, a Mouse Odorant Receptor with an Unusually Broad Response Profile

被引：79

作者：

Grosmaitre, Xavier ^{[1
]}

Fuss, Stefan H. ^{[2
,4
]}

Lee, Anderson C. ^{[1
]}

Adipietro, Kaylin A. ^{[3
]}

Matsunami, Hiroaki ^{[3
]}

Mombaerts, Peter ^{[2
,5
]}

Ma, Minghong ^{[1
]}

机构：

[1] Univ Penn, Dept Neurosci, Sch Med, Philadelphia, PA 19104 USA

[2] Rockefeller Univ, New York, NY 10065 USA

[3] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[4] Bogazici Univ, Dept Mol Biol & Genet, TR-34342 Istanbul, Turkey

[5] Max Planck Inst Biophys, Dept Mol Neurogenet, D-60438 Frankfurt, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 46期

基金：

美国国家卫生研究院;

关键词：

OLFACTORY SENSORY NEURONS; FUNCTIONAL EXPRESSION; CLASS-I; IDENTIFICATION; ORGANIZATION; SYSTEM; FAMILY;

D O I：

10.1523/JNEUROSCI.2752-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The current consensus model in mammalian olfaction is that the detection of millions of odorants requires a large number of odorant receptors (ORs) and that each OR interacts selectively with a small subset of odorants, which are typically related in structure. Here, we report the odorant response properties of an OR that deviates from this model: SR1, a mouse OR that is abundantly expressed in sensory neurons of the septal organ and also of the main olfactory epithelium. Patch-clamp recordings reveal that olfactory sensory neurons (OSNs) that express SR1 respond to many, structurally unrelated odorants, and over a wide concentration range. Most OSNs expressing a gene-targeted SR1 locus that lacks the SR1 coding sequence do not show this broad responsiveness. Gene transfer in the heterologous expression system Hana3A confirms the broad response profile of SR1. There may be other mouse ORs with such broad response profiles.

引用

页码：14545 / 14552

页数：8

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