Insulin is a Two-Edged Knife on the Brain

被引：63

作者：

Cardoso, Susana ^{[2
]}

Correia, Sonia ^{[2
]}

Santos, Renato X. ^{[2
]}

Carvalho, Cristina ^{[2
]}

Santos, Maria S. ^{[2
]}

Oliveira, Catarina R. ^{[3
]}

Perry, George ^{[4
,5
]}

Smith, Mark A. ^{[5
]}

Zhu, Xiongwei ^{[5
]}

Moreira, Paula I. ^{[1
]}

机构：

[1] Univ Coimbra, Fac Med, Inst Physiol, Ctr Neurosci & Cell Biol, P-3000354 Coimbra, Portugal

[2] Univ Coimbra, Fac Sci & Technol, Dept Zool, P-3000354 Coimbra, Portugal

[3] Univ Coimbra, Fac Med, Inst Biochem, P-3000354 Coimbra, Portugal

[4] Univ Texas San Antonio, Coll Sci, San Antonio, TX USA

[5] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 18卷 / 03期

关键词：

Brain; insulin; insulin sensitizers; insulin signaling; neurodegenerative disorders; ACTIVATED-RECEPTOR-GAMMA; TRANSGENIC MOUSE MODEL; AMYOTROPHIC-LATERAL-SCLEROSIS; AMYLOID PRECURSOR PROTEIN; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-I; SPORADIC ALZHEIMER-DISEASE; NITRIC-OXIDE SYNTHASE; PERMEABILITY TRANSITION PORE; CEREBRAL GLUCOSE-UTILIZATION;

D O I：

10.3233/JAD-2009-1155

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Insulin, long known as an important regulator of blood glucose levels, plays important and multifaceted roles in the brain. It has been reported that insulin is an important neuromodulator, contributing to several neurobiological processes in particular energy homeostasis and cognition. Dysregulation of insulin signaling has been linked to aging and metabolic and neurodegenerative disorders. The first part of this review is devoted to discussion of the critical role of insulin signaling in normal brain function. Then the involvement of impaired insulin signaling in the pathophysiology of diabetes, Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis will be discussed. Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined.

引用

页码：483 / 507

页数：25

共 289 条

[21] Signaling by insulin-like growth factor 1 in brain [J].

Bondy, CA ;

Cheng, CM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 490 (1-3) :25-31

[22] On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory [J].

Bonini, J. S. ;

Da Silva, W. C. ;

Bevilaqua, L. R. M. ;

Medina, J. H. ;

Izquierdo, I. ;

Cammarota, M. .

NEUROSCIENCE, 2007, 147 (01) :37-45

[23] PPAR:: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases [J].

Bordet, R. ;

Ouk, T. ;

Petrault, O. ;

Gele, P. ;

Gautier, S. ;

Laprais, M. ;

Deplanque, D. ;

Duriez, P. ;

Staels, B. ;

Fruchart, J. C. ;

Bastide, M. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :1341-1346

[24] INSULIN INHIBITS SPECIFIC NOREPINEPHRINE UPTAKE IN NEURONAL CULTURES FROM RAT-BRAIN [J].

BOYD, FT ;

CLARKE, DW ;

RAIZADA, MK .

BRAIN RESEARCH, 1986, 398 (01) :1-5

[25] The effects of type 1 diabetes on cognitive performance - A meta-analysis [J].

Brands, AMA ;

Biessels, GJ ;

De Haan, EHF ;

Kappelle, LJ ;

Kessels, RPC .

DIABETES CARE, 2005, 28 (03) :726-735

[26] Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels [J].

Brands, AMA ;

Kessels, RPC ;

de Haan, EHF ;

Kappelle, LJ ;

Biessels, GJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 490 (1-3) :159-168

[27] Protective action of the peroxisome proliferator-activated receptor-γ agonist pioglitazone in a mouse model of Parkinson's disease [J].

Breidert, T ;

Callebert, J ;

Heneka, MT ;

Landreth, G ;

Launay, JM ;

Hirsch, EC .

JOURNAL OF NEUROCHEMISTRY, 2002, 82 (03) :615-624

[28] Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons [J].

Brodbeck, Jens ;

Balestra, Maureen E. ;

Saunders, Ann M. ;

Roses, Allen D. ;

Mahley, Robert W. ;

Huang, Yadong .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (04) :1343-1346

[29] Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia [J].

Browne, SE ;

Bowling, AC ;

MacGarvey, U ;

Baik, MJ ;

Berger, SC ;

Muqit, MMK ;

Bird, ED ;

Beal, MF .

ANNALS OF NEUROLOGY, 1997, 41 (05) :646-653

[30] Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway [J].

Brunet, A ;

Datta, SR ;

Greenberg, ME .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :297-305

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