Shape Changes of the Basal Ganglia and Thalamus in Alzheimer's Disease: A Three-Year Longitudinal Study

被引：73

作者：

Cho, Hanna ^{[1
,2
]}

Kim, Jeong-Hun ^{[3
]}

Kim, Changsoo ^{[4
,5
]}

Ye, Byoung Seok ^{[1
]}

Kim, Hee Jin ^{[1
]}

Yoon, Cindy W. ^{[1
]}

Noh, Young ^{[1
]}

Kim, Geon Ha ^{[1
]}

Kim, Yeo Jin ^{[1
]}

Kim, Jung-Hyun ^{[1
]}

Kim, Chang-Hun ^{[6
]}

Kang, Sue J. ^{[1
]}

Chin, Juhee ^{[1
]}

Kim, Sung Tae ^{[7
]}

Lee, Kyung-Han ^{[8
]}

Na, Duk L. ^{[1
]}

Seong, Joon-Kyung ^{[9
]}

Seo, Sang Won ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul 135710, South Korea

[2] Yonsei Univ, Coll Med, Dept Neurol, Gangnam Severance Hosp, Seoul, South Korea

[3] Korea Univ, Dept Comp & Radio Commun Engn, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[5] Yonsei Univ, Coll Med, Inst Environm Res, Seoul, South Korea

[6] Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea

[7] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med, Seoul 135710, South Korea

[8] Sungkyunkwan Univ, Samsung Med Ctr, Dept Nucl Med, Sch Med, Seoul 135710, South Korea

[9] Korea Univ, Dept Biomed Engn, Seoul 136703, South Korea

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 40卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; basal ganglia; caudate nucleus; globus pallidus; putamen; shape; thalamus; FRONTOTEMPORAL LOBAR DEGENERATION; SUBCORTICAL STRUCTURES; ATROPHY; ABNORMALITIES; HIPPOCAMPAL; STRIATUM; DEMENTIA; VOLUMES; PATTERNS; AMYGDALA;

D O I：

10.3233/JAD-132072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Background: A large number of Alzheimer's disease (AD) studies have focused on medial temporal and cortical atrophy, while changes in the basal ganglia or thalamus have received less attention. Objective: The aim of this study was to investigate the existence of progressive topographical shape changes in the basal ganglia (caudate nucleus, putamen, and globus pallidus) and thalamus concurrent with AD disease progression over three years. This study also examined whether declines in volumes of the basal ganglia or thalamus might be responsible for cognitive decline in patients with AD. Methods: Thirty-six patients with early stage AD and 14 normal control subjects were prospectively recruited for this study. All subjects were assessed with neuropsychological tests and MRI at baseline and Years 1 and 3. A longitudinal shape analysis of the basal ganglia and thalamus was performed by employing a boundary surface-based shape analysis method. Results: AD patients exhibited specific regional atrophy in the right caudate nucleus and the bilateral putamen at baseline, and as the disease progressed, regional atrophic changes in the left caudate nucleus were found to conform to a distinct topography after controlling the total brain volume. Volumetric decline of the caudate nucleus and putamen correlated with cognitive decline in frontal function after controlling for age, gender, education, follow-up years, and total brain volume changes. Conclusion: Our findings suggest that shape changes of the basal ganglia occurred regardless of whole brain atrophy as AD progressed and were also responsible for cognitive decline that was observed from the frontal function tests.

引用

页码：285 / 295

页数：11

共 52 条

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