Copper-catalyzed coupling of imines, acid chlorides, and alkynes: A multicomponent route to propargylamides

被引：124

作者：

Black, DA ^{[1
]}

Arndtsen, BA ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 07期

关键词：

D O I：

10.1021/ol036462+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of imines in a metal-catalyzed coupling with alkynes and acid chlorides is described. This process proceeds rapidly with Cul as the catalyst and provides an efficient and general three-component coupling method to prepare propargylamides. The coupling can also be diversified to allow the formation of N-carbamate-protected propargylamines with the use of chloroformates.

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页码：1107 / 1110

页数：4

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