A new class of C-elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of ras signaling

被引:111
作者
Ceol, CJ [1 ]
Horvitz, HR [1 ]
机构
[1] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S1534-5807(04)00065-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegrans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.
引用
收藏
页码:563 / 576
页数:14
相关论文
共 53 条
  • [41] SIGURDSON DC, 1984, GENETICS, V108, P331
  • [42] Sinclair DAR, 1998, GENETICS, V148, P211
  • [43] NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans
    Solari, F
    Ahringer, J
    [J]. CURRENT BIOLOGY, 2000, 10 (04) : 223 - 226
  • [44] PATTERN-FORMATION DURING VULVAR DEVELOPMENT IN C-ELEGANS
    STERNBERG, PW
    HORVITZ, HR
    [J]. CELL, 1986, 44 (05) : 761 - 772
  • [45] Genetics of RAS signaling in C-elegans
    Sternberg, PW
    Han, M
    [J]. TRENDS IN GENETICS, 1998, 14 (11) : 466 - 472
  • [46] POST-EMBRYONIC CELL LINEAGES OF NEMATODE, CAENORHABDITIS-ELEGANS
    SULSTON, JE
    HORVITZ, HR
    [J]. DEVELOPMENTAL BIOLOGY, 1977, 56 (01) : 110 - 156
  • [47] ABNORMAL-CELL LINEAGES IN MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS
    SULSTON, JE
    HORVITZ, HR
    [J]. DEVELOPMENTAL BIOLOGY, 1981, 82 (01) : 41 - 55
  • [48] The rde-1 gene, RNA interference, and transposon silencing in C-elegans
    Tabara, H
    Sarkissian, M
    Kelly, WG
    Fleenor, J
    Grishok, A
    Timmons, L
    Fire, A
    Mello, CC
    [J]. CELL, 1999, 99 (02) : 123 - 132
  • [49] MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN31 WH transcription factor complex during C-elegans vulval induction
    Tan, PB
    Lackner, MR
    Kim, SK
    [J]. CELL, 1998, 93 (04) : 569 - 580
  • [50] Thomas JH, 1999, DEVELOPMENT, V126, P3449