The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegrans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Osada, S
Sutton, A
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机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Sutton, A
Muster, N
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机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Muster, N
Brown, CE
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机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Brown, CE
Yates, JR
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机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Yates, JR
Sternglanz, R
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机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Sternglanz, R
Workman, JL
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Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Osada, S
Sutton, A
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Sutton, A
Muster, N
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Muster, N
Brown, CE
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Brown, CE
Yates, JR
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Yates, JR
Sternglanz, R
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA
Sternglanz, R
Workman, JL
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, HHMI, University Pk, PA 16802 USA