A new class of C-elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of ras signaling

被引:111
作者
Ceol, CJ [1 ]
Horvitz, HR [1 ]
机构
[1] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S1534-5807(04)00065-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegrans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.
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收藏
页码:563 / 576
页数:14
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