The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

被引：357

作者：

McMahon, SB ^{[1
]}

Wood, MA ^{[1
]}

Cole, MD ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2000年 / 20卷 / 02期

关键词：

D O I：

10.1128/MCB.20.2.556-562.2000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined. We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein. Since c-Myc function is inhibited by recruitment of histone deacetylase activity through Mad family proteins, these opposing biochemical activities are likely to be responsible for the antagonistic biological effects of c-Myc and Mad on target genes and ultimately on cellular transformation.

引用

页码：556 / 562

页数：7

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