The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

被引：357

作者：

McMahon, SB ^{[1
]}

Wood, MA ^{[1
]}

Cole, MD ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2000年 / 20卷 / 02期

关键词：

D O I：

10.1128/MCB.20.2.556-562.2000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical and genetic pathways leading to transformation remain undefined. We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein. Since c-Myc function is inhibited by recruitment of histone deacetylase activity through Mad family proteins, these opposing biochemical activities are likely to be responsible for the antagonistic biological effects of c-Myc and Mad on target genes and ultimately on cellular transformation.

引用

页码：556 / 562

页数：7

共 53 条

[11]

Dang CV, 1999, MOL CELL BIOL, V19, P1

[12] The molecular role of Myc in growth and transformation: recent discoveries lead to new insights [J].

Facchini, LM ;

Penn, LZ .

FASEB JOURNAL, 1998, 12 (09) :633-651

[13] 2 DISTINCT YEAST TRANSCRIPTIONAL ACTIVATORS REQUIRE THE FUNCTION OF THE GCN5 PROTEIN TO PROMOTE NORMAL LEVELS OF TRANSCRIPTION [J].

GEORGAKOPOULOS, T ;

THIREOS, G .

EMBO JOURNAL, 1992, 11 (11) :4145-4152

[14]

GORUPPI S, 1994, ONCOGENE, V9, P1537

[15] Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex [J].

Grant, PA ;

Duggan, L ;

Cote, J ;

Roberts, SM ;

Brownell, JE ;

Candau, R ;

Ohba, R ;

OwenHughes, T ;

Allis, CD ;

Winston, F ;

Berger, SL ;

Workman, JL .

GENES & DEVELOPMENT, 1997, 11 (13) :1640-1650

[16] The ATM-related cofactor Tra1 is a component of the purified SAGA complex [J].

Grant, PA ;

Schieltz, D ;

Pray-Grant, MG ;

Yates, JR ;

Workman, JL .

MOLECULAR CELL, 1998, 2 (06) :863-867

[17] Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain [J].

Gu, W ;

Roeder, RG .

CELL, 1997, 90 (04) :595-606

[18] Histone deacetylase activity is required for full transcriptional repression by mSin3A [J].

Hassig, CA ;

Fleischer, TC ;

Billin, AN ;

Schreiber, SL ;

Ayer, DE .

CELL, 1997, 89 (03) :341-347

[19]

HORIUCHI J, 1995, MOL CELL BIOL, V15, P1203

[20]

HURLIN PJ, 1995, EMBO J, V14, P223

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