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Mechanisms of selection and differentiation in germinal centers

被引：51
作者：
Liu, YJ
deBouteiller, O
FugierVivier, I
机构：
[1] Schering-Plough, Lab. Immunological Res., 69571 Cedex, Dardilly
来源：
CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0952-7915(97)80145-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The choice between death and survival, a feature of early B cell development, is a choice also faced by mature B cells. If they survive this early developmental decision, mature B cells then face a second choice: either to undergo either terminal differentiation into plasma cells or to differentiate into memory B cells. Antigens, T cell signals (cytokines, CD40 ligand and Fas ligand) as well as the activation state of B cells determine their ultimate fate.
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收藏
页码：256 / 262
页数：7
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