Mechanisms of selection and differentiation in germinal centers

被引：51

作者：

Liu, YJ

deBouteiller, O

FugierVivier, I

机构：

[1] Schering-Plough, Lab. Immunological Res., 69571 Cedex, Dardilly

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(97)80145-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The choice between death and survival, a feature of early B cell development, is a choice also faced by mature B cells. If they survive this early developmental decision, mature B cells then face a second choice: either to undergo either terminal differentiation into plasma cells or to differentiate into memory B cells. Antigens, T cell signals (cytokines, CD40 ligand and Fas ligand) as well as the activation state of B cells determine their ultimate fate.

引用

页码：256 / 262

页数：7

共 56 条

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