Modern aldol methods for the total synthesis of polyketides

被引：332

作者：

Schetter, Bernd ^{[1
]}

Mahrwald, Rainer ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 45期

关键词：

aldol reaction; asymmetric synthesis; enantioselectivity; natural products; polyketides;

D O I：

10.1002/anie.200602780

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7506 / 7525

页数：20

共 206 条

[31] Total synthesis and structural elucidation of (-)-maurenone [J].