Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

被引：26

作者：

Ang, Wee Han ^{[1
]}

Grote, Zacharias ^{[1
]}

Scopelliti, Rosario ^{[1
]}

Juillerat-Jeanneret, Lucienne ^{[2
]}

Severin, Kay ^{[1
]}

Dyson, Paul J. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[2] CHU Vaudois, Univ Inst Pathol, CH-1011 Lausanne, Switzerland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2009年 / 694卷 / 06期

关键词：

Bioorganometallic; Anticancer drugs; Medicinal chemistry; X-ray crystallography; Ruthenium; Rhodium; VITRO ANTICANCER ACTIVITY; IRON-DEFICIENCY ANEMIA; IN-VITRO; METAL-COMPLEXES; RUTHENIUM COMPLEXES; ARENE COMPLEXES; ANTITUMOR DRUGS; PTA COMPLEXES; WATER; CHEMISTRY;

D O I：

10.1016/j.jorganchem.2008.11.026

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Organometallic half-sandwich complexes based on ruthenium with aminomethyl-substituted 3-hydroxy-2-pyridone ligands exist in aqueous solution as monomeric O,O'-chelate complexes or trimeric metallamacrocycles depending upon the pH. We hypothesized that administration of the compounds as stable trimers, which subsequently convert to active monomers at the reduced pH of the cancer environment, could facilitate their delivery to cancer cells without undergoing deactivation. Thus, the compounds were evaluated against cancer and fibroblast cell lines in vitro. A series of rhodium complexes, which exist mainly as monomers at neutral pH, were also studied for comparative purposes. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：968 / 972

页数：5

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