Controlled release of proteins to tissue transplants for the treatment of neurodegenerative disorders

被引：49

作者：

Mahoney, MJ ^{[1
]}

Saltzman, WM ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, DEPT CHEM ENGN, BALTIMORE, MD 21218 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1996年 / 85卷 / 12期

基金：

美国国家航空航天局;

关键词：

D O I：

10.1021/js9601602

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease involves substantial cholinergic cell deficits; other neurodegenerative diseases involve similar losses of certain cell populations. Optimal therapies may involve tissue replacement coupled with the controlled delivery of appropriate growth factors, such as nerve growth factor, to the graft site. In this review article we describe the kinetics of protein release from three modes of controlled protein delivery to transplants: delivery from a polymer matrix, delivery form polymeric microspheres, and delivery from genetically engineered cells. The efficacy and feasibility of each of these delivery strategies for potential treatment of patients diagnosed with neurodegenerative disorders is discussed.

引用

页码：1276 / 1281

页数：6

共 46 条

[31]

NIIJIMA K, 1995, J NEUROSCI, V15, P1180

[32]

OGAWA Y, 1988, CHEM PHARM BULL, V36, P2576

[33] ROLE OF GROWTH-FACTORS IN DEGENERATION AND REGENERATION IN THE CENTRAL-NERVOUS-SYSTEM - CLINICAL-EXPERIENCES WITH NGF IN PARKINSONS AND ALZHEIMERS DISEASES [J].

OLSON, L ;

BACKMAN, L ;

EBENDAL, T ;

ERIKSDOTTERJONHAGEN, M ;

HOFFER, B ;

HUMPEL, C ;

FREEDMAN, R ;

GIACOBINI, M ;

MEYERSON, B ;

NORDBERG, A ;

SEIGER, A ;

STROMBERG, I ;

SYDOW, O ;

TOMAC, A ;

TROK, K ;

WINBLAD, B .

JOURNAL OF NEUROLOGY, 1994, 242 (01) :S12-S15

[34]

PHELPS CH, 1989, SCIENCE, V243, P11

[35] MACROMOLECULAR PERMEABILITY ACROSS THE BLOOD-NERVE AND BLOOD-BRAIN BARRIERS [J].

PODUSLO, JF ;

CURRAN, GL ;

BERG, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5705-5709

[36] CONTROLLED RELEASE OF NERVE GROWTH-FACTOR FROM A POLYMERIC IMPLANT [J].

POWELL, EM ;

SOBARZO, MR ;

SALTZMAN, WM .

BRAIN RESEARCH, 1990, 515 (1-2) :309-311

[37] CONTROLLED-RELEASE OF POLYPEPTIDES FROM POLYANHYDRIDES [J].

RON, E ;

TUREK, T ;

MATHIOWITZ, E ;

CHASIN, M ;

HAGEMAN, M ;

LANGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4176-4180

[38] GRAFTING GENETICALLY MODIFIED CELLS TO THE DAMAGED BRAIN - RESTORATIVE EFFECTS OF NGF EXPRESSION [J].

ROSENBERG, MB ;

FRIEDMANN, T ;

ROBERTSON, RC ;

TUSZYNSKI, M ;

WOLFF, JA ;

BREAKEFIELD, XO ;

GAGE, FH .

SCIENCE, 1988, 242 (4885) :1575-1578

[39] DRUGS RELEASED FROM POLYMERS - DIFFUSION AND ELIMINATION IN BRAIN-TISSUE [J].

SALTZMAN, WM ;

RADOMSKY, ML .

CHEMICAL ENGINEERING SCIENCE, 1991, 46 (10) :2429-2444

[40] TRANSPORT RATES OF PROTEINS IN POROUS MATERIALS WITH KNOWN MICROGEOMETRY [J].

SALTZMAN, WM ;

LANGER, R .

BIOPHYSICAL JOURNAL, 1989, 55 (01) :163-171

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