Telomerase in brain tumors

被引:36
作者
Falchetti, ML
Larocca, LM
Pallini, R
机构
[1] CNR, Inst Neurobiol & Mol Med, I-00137 Rome, Italy
[2] Univ Cattolica, Inst Pathol Anat, I-00168 Rome, Italy
[3] Univ Cattolica, Inst Neurosurg, I-00168 Rome, Italy
关键词
telomerase; brain tumors; tumorigenesis; cell immortalization;
D O I
10.1007/s00381-002-0562-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: In recent years, many scientists involved in cancer research have directed their attention to telomerase, an enzymatic complex which is specifically involved in duplicating telomeres, the very ends of linear chromosomes. The discovery that most immortal cell lines in vitro and human tumor cells in vivo have telomerase activity, in contrast to telomerase-negative normal somatic cells, has made telomerase a candidate for use as a molecular marker of malignancy and even as a target for anticancer therapies. Thus, the assessment of the role of telomerase activity in neoplastic transformation has become a key issue in oncology, as stated by the exponential increase of papers on telomerase in the last 5 years. Object: In this paper, we review some recent data from the literature, including our own studies, on the regulation of telomerase activity in brain tumors.
引用
收藏
页码:112 / 117
页数:6
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