Nitrobenzylation of α-carbonyl ester derivatives using TDAE approach

被引：45

作者：

Giuglio-Tonolo, G

Terme, T

Médebielle, M

Vanelle, P

机构：

[1] Univ Aix Marseille 2, Fac Pharm, CNRS, LCOP,UMR 6517, F-13385 Marseille 05, France

[2] Univ Lyon 1, Lab SERCOF, CNRS, UMR 5181, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 26期

关键词：

TDAE; p-nitrobenzyl chloride; alpha-carbonyl ester; alpha-hydroxy ester;

D O I：

10.1016/j.tetlet.2004.04.166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-hydroxy-propionic acid ethyl ester derivatives was prepared in good yields by reaction of o- and p-nitrobenzyl chlorides (1, 8) with various alpha-carbonyl esters in presence of tetrakis(dimethylamino)ethylene (TDAE). This reaction was generalized to alpha-ketolactain and alpha-ketomalonate. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：5121 / 5124

页数：4

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