Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study

被引：75

作者：

Cherbuin, Nicolas ^{[1
]}

Reglade-Meslin, Chantal ^{[1
]}

Kumar, Rajeev ^{[1
,2
]}

Jacomb, Patricia ^{[1
]}

Easteal, Simon ^{[3
]}

Christensen, Helen ^{[1
]}

Sachdev, Perminder ^{[4
,5
]}

Anstey, Kaarin J. ^{[1
]}

机构：

[1] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, Dept Psychol Med, Canberra, ACT 0200, Australia

[3] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

[4] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia

[5] Inst Neuropsychiat, Sydney, NSW, Australia

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Mild cognitive impairment; Alcohol; Hypertension; BMI; Depression; IDENTIFICATION TEST AUDIT; ALZHEIMERS-DISEASE; ALCOHOL-CONSUMPTION; COMMUNITY SAMPLE; BLOOD-PRESSURE; TOTAL HEALTH; IMPAIRMENT; DEMENTIA; PROGRESSION; PERSONALITY;

D O I：

10.1159/000229025

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community. Copyright (c) 2009 S. Karger AG, Basel

引用

页码：47 / 55

页数：9

共 44 条

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