Asymmetric hydrogenation with antibody-achiral rhodium complex

被引：48

作者：

Yamaguchi, Hiroyasu ^{[1
]}

Hirano, Tohko ^{[1
]}

Kiminami, Hideaki ^{[1
]}

Taura, Daisuke ^{[1
]}

Harada, Akira ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Macromol Sci, Osaka 5600043, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 19期

关键词：

D O I：

10.1039/b609242j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.

引用

页码：3571 / 3573

页数：3

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