Role of the survivin gene in pathophysiology

被引:121
作者
Li, Fengzhi
Brattain, Michael G.
机构
[1] New York State Dept Hlth, Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA
[2] New York State Dept Hlth, Roswell Pk Canc Inst, Grace Canc Drug Ctr, Buffalo, NY 14263 USA
[3] Tongji Univ, Inst Canc, Shanghai 200092, Peoples R China
[4] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
关键词
D O I
10.2353/ajpath.2006.060121
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.
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页码:1 / 11
页数:11
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