Role of the survivin gene in pathophysiology

被引:121
作者
Li, Fengzhi
Brattain, Michael G.
机构
[1] New York State Dept Hlth, Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA
[2] New York State Dept Hlth, Roswell Pk Canc Inst, Grace Canc Drug Ctr, Buffalo, NY 14263 USA
[3] Tongji Univ, Inst Canc, Shanghai 200092, Peoples R China
[4] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
关键词
D O I
10.2353/ajpath.2006.060121
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 76 条
[61]   Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 tax in hematopoietic progenitor (CD34+) cells:: Modulation of p21cip1/waf1 and p27kip1 expression [J].
Tripp, A ;
Banerjee, P ;
Sieburg, M ;
Planelles, V ;
Li, FZ ;
Feuer, G .
JOURNAL OF VIROLOGY, 2005, 79 (22) :14069-14078
[62]   Survivin gene expression in endometriosis [J].
Ueda, M ;
Yamashita, Y ;
Takehara, M ;
Terai, Y ;
Kumagai, K ;
Ueki, K ;
Kanda, K ;
Yamaguchi, H ;
Akise, D ;
Hung, YC ;
Ueki, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (07) :3452-3459
[63]   Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype [J].
Uren, AG ;
Wong, L ;
Pakusch, M ;
Fowler, KJ ;
Burrows, FJ ;
Vaux, DL ;
Choo, KHA .
CURRENT BIOLOGY, 2000, 10 (21) :1319-1328
[64]  
Wall NR, 2003, CANCER RES, V63, P230
[65]   Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis [J].
Wang, KW ;
Brems, JJ ;
Gamelli, RL ;
Ding, JW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (25) :23490-23495
[66]   EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway [J].
Wang, Q ;
Greene, MI .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2005, 79 (02) :100-107
[67]   Survivin expression in rat testis is upregulated by stem-cell factor [J].
Wang, YY ;
Suominen, JS ;
Hakovirta, H ;
Parvinen, M ;
Martinand-Mari, C ;
Toppari, J ;
Robbins, I .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2004, 218 (1-2) :165-174
[68]   Survivin regulates the p53 tumor suppressor gene family [J].
Wang, ZX ;
Fukuda, S ;
Pelus, LM .
ONCOGENE, 2004, 23 (49) :8146-8153
[69]   Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients [J].
Weikert, S ;
Christoph, F ;
Schulze, W ;
Krause, H ;
Kempkensteffen, C ;
Schostak, M ;
Miller, K ;
Schrader, M .
ASIAN JOURNAL OF ANDROLOGY, 2006, 8 (01) :95-100
[70]   The inhibitor of apoptosis (IAP) survivin is expressed in human testicular germ cell tumors and normal testes [J].
Weikert, S ;
Schrader, M ;
Krause, H ;
Schulze, W ;
Müller, M ;
Miller, K .
CANCER LETTERS, 2005, 223 (02) :331-337