Motor cortex excitability in Alzheimer's disease and in subcortical ischemic vascular dementia

被引：41

作者：

Alagona, G

Ferri, R

Pennisi, G

Carnemolla, A

Maci, T

Domina, E

de Noordhout, AM

Bella, R

机构：

[1] Univ Catania, Azienda Policlin, Dept Neurol Sci, I-95123 Catania, Italy

[2] IRCCS Oasi, Dept Neurol, Troina, EN, Italy

[3] Hop Citadelle, Dept Neurol, Liege, Belgium

来源：

NEUROSCIENCE LETTERS | 2004年 / 362卷 / 02期

关键词：

Alzheimer's disease; subcortical ischemic vascular dementia; motor cortex excitability; transcranial magnetic stimulation;

D O I：

10.1016/j.neulet.2004.03.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Twenty Alzheimer's disease (AD) patients, 20 subcortical ischemic vascular dementia (SIVD) patients and 20 neurologically and cognitively normal subjects underwent transcranial magnetic stimulation to study motor cortex excitability changes. Motor threshold (NIT), amplitude of motor evoked potentials, silent period and the H/M ratio (amplitude of maximal Hoffman reflex vs. that of maximal motor response) were considered. MT was lower in SIVD patients when compared with AD patients (P = 0.003) and the control group (P < 0.001) and lower in AD patients when compared with the control group (P < 0.001). The increment of motor cortex excitability in AD and SIVD did not lead us to distinguish clearly the two types of dementia. It is likely that the electrophysiological similarity between AD and SIVD could represent another common mechanism shared from these forms of dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 98

页数：4

共 20 条

[11] Motor cortex disinhibition in Alzheimer's disease [J].

Liepert, J ;

Bär, KJ ;

Meske, U ;

Weiller, C .

CLINICAL NEUROPHYSIOLOGY, 2001, 112 (08) :1436-1441

[12]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[13] NONCOMPETITIVE NMDA RECEPTOR ANTAGONISTS WITH FAST OPEN-CHANNEL BLOCKING KINETICS AND STRONG VOLTAGE-DEPENDENCY AS POTENTIAL THERAPEUTIC AGENTS FOR ALZHEIMERS DEMENTIA [J].

MULLER, WE ;

MUTSCHLER, E ;

RIEDERER, P .

PHARMACOPSYCHIATRY, 1995, 28 (04) :113-124

[14] Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex [J].

Peinemann, A ;

Lehner, C ;

Conrad, B ;

Siebner, HR .

NEUROSCIENCE LETTERS, 2001, 313 (1-2) :33-36

[15] Transcranial magnetic stimulation after pure motor stroke [J].

Pennisi, G ;

Alagona, G ;

Rapisarda, G ;

Nicoletti, F ;

Costanzo, E ;

Ferri, R ;

Malaguarnera, M ;

Bella, R .

CLINICAL NEUROPHYSIOLOGY, 2002, 113 (10) :1536-1543

[16] Motor cortex excitability in Alzheimer disease: one year follow-up study [J].

Pennisi, G ;

Alagona, G ;

Ferri, R ;

Greco, S ;

Santonocito, D ;

Pappalardo, A ;

Bella, R .

NEUROSCIENCE LETTERS, 2002, 329 (03) :293-296

[17] Motor cortex inhibition is not impaired in patients with Alzheimer's disease: evidence from paired transcranial magnetic stimulation [J].

Pepin, JL ;

Bogacz, D ;

de Pasqua, V ;

Delwaide, PJ .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 170 (02) :119-123

[18] VASCULAR DEMENTIA - DIAGNOSTIC-CRITERIA FOR RESEARCH STUDIES - REPORT OF THE NINDS-AIREN INTERNATIONAL WORKSHOP [J].

ROMAN, GC ;

TATEMICHI, TK ;

ERKINJUNTTI, T ;

CUMMINGS, JL ;

MASDEU, JC ;

GARCIA, JH ;

AMADUCCI, L ;

ORGOGOZO, JM ;

BRUN, A ;

HOFMAN, A ;

MOODY, DM ;

OBRIEN, MD ;

YAMAGUCHI, T ;

GRAFMAN, J ;

DRAYER, BP ;

BENNETT, DA ;

FISHER, M ;

OGATA, J ;

KOKMEN, E ;

BERMEJO, F ;

WOLF, PA ;

GORELICK, PB ;

BICK, KL ;

PAJEAU, AK ;

BELL, MA ;

DECARLI, C ;

CULEBRAS, A ;

KORCZYN, AD ;

BOGOUSSLAVSKY, J ;

HARTMANN, A ;

SCHEINBERG, P .

NEUROLOGY, 1993, 43 (02) :250-260

[19] NONINVASIVE ELECTRICAL AND MAGNETIC STIMULATION OF THE BRAIN, SPINAL-CORD AND ROOTS - BASIC PRINCIPLES AND PROCEDURES FOR ROUTINE CLINICAL-APPLICATION - REPORT OF AN IFCN COMMITTEE [J].

ROSSINI, PM ;

BARKER, AT ;

BERARDELLI, A ;

CARAMIA, MD ;

CARUSO, G ;

CRACCO, RQ ;

DIMITRIJEVIC, MR ;

HALLETT, M ;

KATAYAMA, Y ;

LUCKING, CH ;

DENOORDHOUT, ALM ;

MARSDEN, CD ;

MURRAY, NMF ;

ROTHWELL, JC ;

SWASH, M ;

TOMBERG, C .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1994, 91 (02) :79-92

[20] BRAIN EXCITABILITY AND LONG LATENCY MUSCULAR ARM RESPONSES - NONINVASIVE EVALUATION IN HEALTHY AND PARKINSONIAN SUBJECTS [J].

ROSSINI, PM ;

PARADISO, C ;

ZAROLA, F ;

BERNARDI, G ;

CARAMIA, MD ;

MARGARI, L ;

FERRARI, E .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1991, 81 (06) :454-465

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