Viral vectors for modulating gene expression in neurons

被引：59

作者：

Slack, RS

Miller, FD

机构：

[1] Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Que. H3A 2B4

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(96)80088-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology: Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses have proved to be efficient, non-cytotoxic vectors for manipulating neurons in dissociated and organotypic cultures, when used at low viral titres. In contrast, vectors derived from herpes simplex virus 1 still suffer from concerns regarding cellular cytotoxicity, in spite of several generations of vector development; however, recent advances in amplicon technology may solve this problem. Finally, several new-generation vectors, including those generated from adeno-associated virus, show great promise as neuronal gene-transfer vectors in vivo.

引用

页码：576 / 583

页数：8

共 53 条

[1] Dystrophin expression in muscles of mdx mice after adenovirus-mediated in vivo gene transfer
Acsadi, G
Lochmuller, H
Jani, A
Huard, J
Massie, B
Prescott, S
Simoneau, M
Petrof, BJ
Karpati, G
[J]. HUMAN GENE THERAPY, 1996, 7 (02) : 129 - 140
[2] TRANSFER OF A FOREIGN GENE INTO THE BRAIN USING ADENOVIRUS VECTORS
AKLI, S
CAILLAUD, C
VIGNE, E
STRATFORDPERRICAUDET, LD
POENARU, L
PERRICAUDET, M
KAHN, A
PESCHANSKI, MR
[J]. NATURE GENETICS, 1993, 3 (03) : 224 - 228
[3] ALI M, 1994, GENE THER, V1, P367
[4] GENE-TRANSFER INTO MAMMALIAN CENTRAL-NERVOUS-SYSTEM USING HERPES-VIRUS VECTORS - EXTENDED EXPRESSION OF BACTERIAL LACZ IN NEURONS USING THE NEURON-SPECIFIC ENOLASE PROMOTER
ANDERSEN, JK
GARBER, DA
MEANEY, CA
BREAKEFIELD, XO
[J]. HUMAN GENE THERAPY, 1992, 3 (05) : 487 - 499
[5] DIRECT INVIVO GENE-TRANSFER TO EPENDYMAL CELLS IN THE CENTRAL-NERVOUS-SYSTEM USING RECOMBINANT ADENOVIRUS VECTORS
BAJOCCHI, G
FELDMAN, SH
CRYSTAL, RG
MASTRANGELI, A
[J]. NATURE GENETICS, 1993, 3 (03) : 229 - 234
[6] An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity
Barkats, M
Bemelmans, AP
Geoffroy, MC
Robert, JJ
Loquet, I
Horellou, P
Revah, F
Mallet, J
[J]. NEUROREPORT, 1996, 7 (02) : 497 - 501
[7] BATTLEMAN DS, 1993, J NEUROSCI, V13, P941
[8] TRANSSYNAPTIC NEURONAL LOSS INDUCED IN HIPPOCAMPAL SLICE CULTURES BY A HERPES-SIMPLEX VIRUS VECTOR EXPRESSING THE GLUR6 SUBUNIT OF THE KAINATE RECEPTOR
BERGOLD, PJ
CASACCIABONNEFIL, P
ZENG, XL
FEDEROFF, HJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) : 6165 - 6169
[9] AN EFFICIENT AND FLEXIBLE SYSTEM FOR CONSTRUCTION OF ADENOVIRUS VECTORS WITH INSERTIONS OR DELETIONS IN EARLY REGION-1 AND REGION-3
BETT, AJ
HADDARA, W
PREVEC, L
GRAHAM, FL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) : 8802 - 8806
[10] GENE-TRANSFER INTO EXPERIMENTAL BRAIN-TUMORS MEDIATED BY ADENOVIRUS, HERPES-SIMPLEX VIRUS, AND RETROVIRUS VECTORS
BOVIATSIS, EJ
CHASE, M
WEI, MX
TAMIYA, T
HURFORD, RK
KOWALL, NW
TEPPER, RI
BREAKEFIELD, XO
CHIOCCA, EA
[J]. HUMAN GENE THERAPY, 1994, 5 (02) : 183 - 191

← 1 2 3 4 5 6 →