Viral vectors for modulating gene expression in neurons

被引:59
作者
Slack, RS
Miller, FD
机构
[1] Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Que. H3A 2B4
关键词
D O I
10.1016/S0959-4388(96)80088-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology: Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses have proved to be efficient, non-cytotoxic vectors for manipulating neurons in dissociated and organotypic cultures, when used at low viral titres. In contrast, vectors derived from herpes simplex virus 1 still suffer from concerns regarding cellular cytotoxicity, in spite of several generations of vector development; however, recent advances in amplicon technology may solve this problem. Finally, several new-generation vectors, including those generated from adeno-associated virus, show great promise as neuronal gene-transfer vectors in vivo.
引用
收藏
页码:576 / 583
页数:8
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