Mechanism of action studies of cytotoxic marine alkaloids: ascididemin exhibits thiol-dependent oxidative DNA cleavage

被引：30

作者：

Matsumoto, SS

Sidford, MH

Holden, JA

Barrows, LR ^{[1
]}

Copp, BR

机构：

[1] Univ Utah, Dept Pharmacol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Toxicol, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA

[4] Univ Auckland, Dept Chem, Auckland, New Zealand

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期

关键词：

alkaloid; marine metabolites; cytotoxins;

D O I：

10.1016/S0040-4039(00)00011-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cytotoxic marine alkaloid ascididemin has been shown to be a thiol-dependent DNA cleaving agent. Previous mechanisms of action studies have concluded that DNA and/or the DNA processing enzyme topoisomerase II were the cellular targets for the alkaloid - this is the first direct evidence that a pyridoacridone alkaloid can cause DNA cleavage under physiological conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1667 / 1670

页数：4

共 8 条

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[2]

Bracher F, 1997, PHARMAZIE, V52, P57

[3]

BRACHER F, 1989, LIEBIGS ANN CHEM, P87

[4] Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens [J].