Asymmetric 1,4-reductions of hindered β-substituted cycloalkenones using catalytic SEGPHOS-ligated CuH

被引：96

作者：

Lipshutz, BH ^{[1
]}

Servesko, JM ^{[1
]}

Petersen, TB ^{[1
]}

Papa, PP ^{[1
]}

Lover, AA ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 08期

关键词：

D O I：

10.1021/ol0400185

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reagent combination of catalytic amounts of copper hydride ligated by a nonracemic SEGPHOS ligand leads in situ to an extremely reactive species capable of effecting asymmetric hydrosilylations of conjugated cyclic enones in very high ees. An unprecedented substrate-to-ligand ratio as high as 275 000:1 for this transformation has been documented.

引用

页码：1273 / 1275

页数：3

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