Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity

被引：41

作者：

Stead, P

Hiscox, S

Robinson, PS

Pike, NB

Sidebottom, PJ

Roberts, AD

Taylor, NL

Wright, AE

Pomponi, SA

Langley, D

机构：

[1] Glaxo Wellcome Med Res Ctr, Bioproc Unit, Stevenage SG1 2NY, Herts, England

[2] Glaxo Wellcome Med Res Ctr, Lead Discovery Unit, Stevenage SG1 2NY, Herts, England

[3] Glaxo Wellcome Med Res Ctr, Vasc Dis Unit, Stevenage SG1 2NY, Herts, England

[4] Glaxo Wellcome Med Res Ctr, Phys Sci Unit, Stevenage SG1 2NY, Herts, England

[5] Glaxo Wellcome Med Res Ctr, Compound Divers Unit, Stevenage SG1 2NY, Herts, England

[6] Harbor Branch Oceanog Inst Inc, Ft Pierce, FL 34946 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)00063-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：661 / 664

页数：4

共 11 条

[1] THE STRUCTURE OF ERYLOSIDE A, A NEW ANTITUMOR AND ANTIFUNGAL 4-METHYLATED STEROIDAL GLYCOSIDE FROM THE SPONGE ERYLUS-LENDENFELDI [J].