Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region

被引：125

作者：

Good, M ^{[1
]}

Day, M ^{[1
]}

Muir, JL ^{[1
]}

机构：

[1] Cardiff Univ, Sch Psychol, Cardiff CF11 3YG, S Glam, Wales

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1999年 / 11卷 / 12期

关键词：

hippocampus; LTD; LTP; oestrogen; paired pulse; synaptic plasticity;

D O I：

10.1046/j.1460-9568.1999.00920.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigated the effects of naturally fluctuating endogenous levels of oestrogen on the induction and maintenance of long-term potentiation (LTP) and long-term depression (LTD) in the CA1 region of the hippocampus. Using an anaesthetized in vivo preparation, the results showed that the induction of LTP was augmented during the pro-oestrous stage of the oestrous cycle. In contrast to LTP, however, the induction of paired-pulse LTD was severely attenuated during pro-oestrous, but was clearly manifested by rats during met/dioestrous and oestrous stages of the cycle. These findings are discussed with reference to: (i) the modulatory effects of oestrogen on N-methyl-d-aspartate (NMDA) receptor function and gamma-aminobutyric acid (GABA) neurotransmission in the hippocampus; and (ii) the functional implications that such cyclical changes in synaptic plasticity have for learning and memory processes supported by the hippocampus.

引用

页码：4476 / 4480

页数：5

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