The trypanosomal trans-sialidase: Two catalytic functions associated with one catalytic site

被引：10

作者：

Colman, PM ^{[1
]}

Smith, BJ ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

STRUCTURE | 2002年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0969-2126(02)00888-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the trypanosomal trans-sialidase reveals a canonical sialidase catalytic site elaborated with a conformational switch that creates an adjacent binding pocket for lactose.

引用

页码：1466 / 1468

页数：3

共 10 条

[1] The Protein Data Bank [J].

Berman, HM ;

Westbrook, J ;

Feng, Z ;

Gilliland, G ;

Bhat, TN ;

Weissig, H ;

Shindyalov, IN ;

Bourne, PE .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242

[2] Structural basis of sialyltransferase activity in trypanosomal sialidases [J].

Buschiazzo, A ;

Tavares, GA ;

Campetella, O ;

Spinelli, S ;

Cremona, ML ;

París, G ;

Amaya, MF ;

Frasch, ACC ;

Alzari, PM .

EMBO JOURNAL, 2000, 19 (01) :16-24

[3] The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis [J].

Buschiazzo, A ;

Amaya, MF ;

Cremona, ML ;

Frasch, AC ;

Alzari, PM .

MOLECULAR CELL, 2002, 10 (04) :757-768

[4] Neuraminidase inhibitors as antivirals [J].

Colman, PM .

VACCINE, 2002, 20 :S55-S58

[5] INFLUENZA-VIRUS NEURAMINIDASE - STRUCTURE, ANTIBODIES, AND INHIBITORS [J].

COLMAN, PM .

PROTEIN SCIENCE, 1994, 3 (10) :1687-1696

[6]

Crennell S, 2000, NAT STRUCT BIOL, V7, P1068

[7] Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity [J].

Kim, CU ;

Lew, W ;

Williams, MA ;

Liu, HT ;

Zhang, LJ ;

Swaminathan, S ;

Bischofberger, N ;

Chen, MS ;

Mendel, DB ;

Tai, CY ;

Laver, WG ;

Stevens, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (04) :681-690

[8] Sialidases: Structures, biological significance and therapeutic potential [J].

Taylor, G .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (06) :830-837

[9] Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase [J].

Varghese, JN ;

Smith, PW ;

Sollis, SL ;

Blick, TJ ;

Sahasrabudhe, A ;

McKimm-Breschkin, JL ;

Colman, PM .

STRUCTURE WITH FOLDING & DESIGN, 1998, 6 (06) :735-746

[10] RATIONAL DESIGN OF POTENT SIALIDASE-BASED INHIBITORS OF INFLUENZA-VIRUS REPLICATION [J].

VONITZSTEIN, M ;

WU, WY ;

KOK, GB ;

PEGG, MS ;

DYASON, JC ;

JIN, B ;

PHAN, TV ;

SMYTHE, ML ;

WHITE, HF ;

OLIVER, SW ;

COLMAN, PM ;

VARGHESE, JN ;

RYAN, DM ;

WOODS, JM ;

BETHELL, RC ;

HOTHAM, VJ ;

CAMERON, JM ;

PENN, CR .

NATURE, 1993, 363 (6428) :418-423

← 1 →