An efficient one-pot synthesis of polyhydroquinoline derivatives through the Hantzsch four component condensation

被引：190

作者：

Donelson, James L.

Gibbs, Richard A.

De, Surya K. ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

[2] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2006年 / 256卷 / 1-2期

关键词：

polyhydroquinoline; Hantzsch reaction; scandium triflate;

D O I：

10.1016/j.molcata.2006.03.079

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

A straightforward and general method has been developed for the synthesis of polyhydroquinolines derivatives by simply combining aldehyde, ethyl acetoacetate, dimedone, and ammonium acetate in the presence of a catalytic amount of scandium triflate. This method is very easy, rapid, and high yielding reaction for the synthesis of polyhydroquinolines. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：309 / 311

页数：3

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