A novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives using ammonium cerium nitrate (CAN)

被引：36

作者：

Itoh, K

Takahashi, S

Ueki, T

Sugiyama, T

Takahashi, TT

Horiuchi, CA

机构：

[1] Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan

[2] Kyoto Univ, Chem Res Inst, Uji, Kyoto 6110011, Japan

[3] Jikei Univ, Sch Med, Dept Chem, Chofu, Tokyo 1828570, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(02)01612-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of dipolarophiles (several alkenes and alkynes) with ammonium cerium(IV) nitrate ((NH4)(2)Ce(NO3)(6), CAN(IV)) in acetone under reflux gave 3-acetylisoxazole derivatives. In the case of acetophenone, 3-benzoylisoxazole derivatives were obtained. Moreover, it was found that yields of isoxazole derivatives were improved using ammonium cerium(III) nitrate tetrahydrate ((NH4)(2)Ce(NO3)(5).4H(2)O, CAN(III))-formic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7035 / 7037

页数：3

共 16 条

[1] Synthesis of new Δ2-isoxazoline derivatives and their pharmacological characterization as β-adrenergic receptor antagonists [J].