A novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives using ammonium cerium nitrate (CAN)

被引:36
作者
Itoh, K
Takahashi, S
Ueki, T
Sugiyama, T
Takahashi, TT
Horiuchi, CA
机构
[1] Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan
[2] Kyoto Univ, Chem Res Inst, Uji, Kyoto 6110011, Japan
[3] Jikei Univ, Sch Med, Dept Chem, Chofu, Tokyo 1828570, Japan
关键词
D O I
10.1016/S0040-4039(02)01612-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of dipolarophiles (several alkenes and alkynes) with ammonium cerium(IV) nitrate ((NH4)(2)Ce(NO3)(6), CAN(IV)) in acetone under reflux gave 3-acetylisoxazole derivatives. In the case of acetophenone, 3-benzoylisoxazole derivatives were obtained. Moreover, it was found that yields of isoxazole derivatives were improved using ammonium cerium(III) nitrate tetrahydrate ((NH4)(2)Ce(NO3)(5).4H(2)O, CAN(III))-formic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7035 / 7037
页数:3
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