Enantioselective addition of diethylzinc to aldehydes using 1,4-aminoalcohols as chiral ligands

被引：30

作者：

Scarpi, D ^{[1
]}

Lo Galbo, F ^{[1
]}

Occhiato, EG ^{[1
]}

Guarna, A ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Chim Organ U Schiff, I-50019 Sesto Fiorentino, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 08期

关键词：

D O I：

10.1016/j.tetasy.2004.03.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Conformationally constrained, optically active 1,4-aminoalcohols have been used Lis chiral ligands in the addition of diethylzinc to aromatic aldehydes. The enantioselectivity was strongly influenced by the N-alkyl group: the best results were achieved with N-ethyl- and N-benzyl-aminoalcohols (ees up to 95% and 81%, respectively). One example of addition to an aliphatic aldehyde is also reported (best ee 61%). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1319 / 1324

页数：6

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