The SWISS-MODEL Repository-new features and functionality

被引：1260

作者：

Bienert, Stefan ^{[1
,2
]}

Waterhouse, Andrew ^{[1
,2
]}

de Beer, Tjaart A. P. ^{[1
,2
]}

Tauriello, Gerardo ^{[1
,2
]}

Studer, Gabriel ^{[1
,2
]}

Bordoli, Lorenza ^{[1
,2
]}

Schwede, Torsten ^{[1
,2
]}

机构：

[1] Univ Basel, Biozentrum, Klingelbergstr 50-70, CH-4056 Basel, Switzerland

[2] Univ Basel, Biozentrum, SIB Swiss Inst Bioinformat, Klingelbergstr 50-70, CH-4056 Basel, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

关键词：

PROTEIN SECONDARY STRUCTURE; GENOMIC THREADING DATABASE; FAMILIES DATABASE; PREDICTION; SEQUENCES; RESOURCE; WORKSHOP; INFORMATION; ANNOTATIONS;

D O I：

10.1093/nar/gkw1132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SWISS-MODEL Repository (SMR) is a database of annotated 3D protein structure models generated by the automated SWISS-MODEL homology modeling pipeline. It currently holds >400 000 high quality models covering almost 20% of SwissProt/UniProtKB entries. In this manuscript, we provide an update of features and functionalities which have been implemented recently. We address improvements in target coverage, model quality estimates, functional annotations and improved in-page visualization. We also introduce a new update concept which includes regular updates of an expanded set of core organism models and UniProtKB-based targets, complemented by user-driven on-demand update of individual models. With the new release of the modeling pipeline, SMR has implemented a REST-API and adopted an open licencing model for accessing model coordinates, thus enabling bulk download for groups of targets fostering re-use of models in other contexts. SMR can be accessed at https://swissmodel.expasy.org/repository.

引用

页码：D313 / D319

页数：7

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