Integrated microfluidics for parallel screening of an in situ click chemistry library

被引：136

作者：

Wang, Jinyi

Sui, Guodong

Mocharla, Vani P.

Lin, Rachel J.

Phelps, Michael E.

Kolb, Hartmuth C.

Tseng, Hsian-Rong

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Crump Inst Mol Imaging, Los Angeles, CA 90095 USA

[2] Siemens Med Solut USA Inc, Culver City, CA 90230 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 32期

关键词：

click chemistry; enzyme catalysis; high-throughput screening; microreactors; parallel synthesis;

D O I：

10.1002/anie.200601677

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

State-of-the-art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in situ click chemistry reactions with reduced consumption of reagents. A proof-of-concept study was performed with the bovine carbonic anhydrase II (bCAII) click chemistry system. (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5276 / 5281

页数：6

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