Wnt signaling involvement in β-amyloid-dependent neurodegeneration

被引：73

作者：

Inestrosa, NC ^{[1
]}

De Ferrari, GV ^{[1
]}

Garrido, JL ^{[1
]}

Alvarez, A ^{[1
]}

Olivares, GH ^{[1
]}

Barría, MI ^{[1
]}

Bronfman, M ^{[1
]}

Chacón, MA ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Ctr Cell Regulat & Pathol, Santiago, Chile

来源：

NEUROCHEMISTRY INTERNATIONAL | 2002年 / 41卷 / 05期

关键词：

Wnt signaling; beta-amyloid; neurodegeneration;

D O I：

10.1016/S0197-0186(02)00056-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-p peptide (Abeta). We have observed that Abeta-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：341 / 344

页数：4

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