Neuronal calcium sensors and synaptic plasticity

被引：42

作者：

Amici, Mascia ^{[1
]}

Doherty, Andrew ^{[1
]}

Jo, Jihoon ^{[2
]}

Jane, David ^{[3
]}

Cho, Kwangwook ^{[2
]}

Collingridge, Graham ^{[1
,2
]}

Dargan, Sheila ^{[3
]}

机构：

[1] Univ Bristol, Dept Anat, MRC Ctr Synapt Plast, Bristol, Avon, England

[2] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, MRC Ctr Synapt Plast, Bristol, Avon, England

[3] Univ Bristol, Dept Physiol & Pharmacol, MRC Ctr Synapt Plast, Bristol, Avon, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

hippocalcin; hippocampus; neuronal calcium sensor (NCS); perirhinal cortex; synaptic plasticity; PROTEIN HIPPOCALCIN; BINDING PROTEIN; ACTIVATION; MEMORY; FAMILY; NCS-1; CELLS; LTD;

D O I：

10.1042/BST0371359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of synaptic plasticity induced, e.g. LTP (long-term potentiation) or LTD (long-term depression). A vast amount of research has been conducted to identify the molecular and cellular signalling pathways underlying LTP and LTD, but many components remain to be identified. Calcium sensor proteins are thought to play an essential role in regulating the initial part of synaptic plasticity signalling pathways. However, there is still a significant gap in knowledge, and it is only recently that evidence for the importance of members of the NCS (neuronal calcium sensor) protein family has started to emerge. The present minireview aims to bring together evidence supporting a role for NCS proteins in plasticity, focusing on emerging roles of NCS-1 and hippocalcin.

引用

页码：1359 / 1363

页数：5

共 18 条

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