Neuroendocrine and Immune Influences on the CNS: It's a Matter of Sex

被引：51

作者：

Bale, Tracy L. ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA

来源：

NEURON | 2009年 / 64卷 / 01期

关键词：

SCHIZOPHRENIA; DEPRESSION; DISORDERS; STRESS; BRAIN; RISK;

D O I：

10.1016/j.neuron.2009.09.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Most neuropsychiatric diseases have a sex bias in their presentation, age of onset, or treatment response. Yet surprisingly, we have considered very little the contribution of the sexually dimorphic brain when thinking about disease etiology and the important influences of the neuroendocrine and immune systems in programming the CNS.

引用

页码：13 / 16

页数：4

共 15 条

[1] Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior [J].

Amateau, SK ;

McCarthy, MM .

NATURE NEUROSCIENCE, 2004, 7 (06) :643-650

[2] What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? [J].

Arnold, Arthur P. ;

Chen, Xuqi .

FRONTIERS IN NEUROENDOCRINOLOGY, 2009, 30 (01) :1-9

[3] Neuroendocrine factors alter host defense by modulating immune function [J].

Butts, Cherie L. ;

Sternberg, Esther M. .

CELLULAR IMMUNOLOGY, 2008, 252 (1-2) :7-15

[4] From inflammation to sickness and depression: when the immune system subjugates the brain [J].

Dantzer, Robert ;

O'Connor, Jason C. ;

Freund, Gregory G. ;

Johnson, Rodney W. ;

Kelley, Keith W. .

NATURE REVIEWS NEUROSCIENCE, 2008, 9 (01) :46-57

[5] Epigenetic influences on brain development and plasticity [J].

Fagiolini, Michela ;

Jensen, Catherine L. ;

Champagne, Frances A. .

CURRENT OPINION IN NEUROBIOLOGY, 2009, 19 (02) :207-212

[6] Prenatal risk factors for autism: comprehensive meta-analysis [J].

Gardener, Hannah ;

Spiegelman, Donna ;

Buka, Stephen L. .

BRITISH JOURNAL OF PSYCHIATRY, 2009, 195 (01) :7-14

[7] Examining the Intersection of Sex and Stress in Modelling Neuropsychiatric Disorders [J].

Goel, N. ;

Bale, T. L. .

JOURNAL OF NEUROENDOCRINOLOGY, 2009, 21 (04) :415-420

[8] Sex, hormones and affective arousal circuitry dysfunction in schizophrenia [J].

Goldstein, Jill M. .

HORMONES AND BEHAVIOR, 2006, 50 (04) :612-622

[9] A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia [J].

Gur, RE ;

Kohler, C ;

Turetsky, BI ;

Siegel, SJ ;

Kanes, SJ ;

Bilker, WB ;

Brennan, AR ;

Gur, RC .

BIOLOGICAL PSYCHIATRY, 2004, 55 (05) :512-517

[10] The link between childhood trauma and depression: Insights from HPA axis studies in humans [J].

Heim, Christine ;

Newport, D. Jeffrey ;

Mletzko, Tanja ;

Miller, Andrew H. ;

Hemeroff, Charles B. .

PSYCHONEUROENDOCRINOLOGY, 2008, 33 (06) :693-710

← 1 2 →