Neuroendocrine and Immune Influences on the CNS: It's a Matter of Sex

被引:51
作者
Bale, Tracy L. [1 ]
机构
[1] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA
关键词
SCHIZOPHRENIA; DEPRESSION; DISORDERS; STRESS; BRAIN; RISK;
D O I
10.1016/j.neuron.2009.09.036
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Most neuropsychiatric diseases have a sex bias in their presentation, age of onset, or treatment response. Yet surprisingly, we have considered very little the contribution of the sexually dimorphic brain when thinking about disease etiology and the important influences of the neuroendocrine and immune systems in programming the CNS.
引用
收藏
页码:13 / 16
页数:4
相关论文
共 15 条
[11]   Depressive disorders and immunity: 20 years of progress and discovery [J].
Irwin, Michael R. ;
Miller, Andrew H. .
BRAIN BEHAVIOR AND IMMUNITY, 2007, 21 (04) :374-383
[12]   Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events [J].
Khashan, Ali S. ;
Abel, Kathryn M. ;
McNamee, Roseanne ;
Pedersen, Marianne G. ;
Webb, Roger T. ;
Baker, Philip N. ;
Kenny, Louise C. ;
Mortensen, Preben Bo .
ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) :146-152
[13]   Glucocorticoids, depression, and mood disorders: structural remodeling in the brain [J].
McEwen, BS .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (05) :20-23
[14]   Sex-specific programming of offspring emotionality after stress early in pregnancy [J].
Mueller, Bridget R. ;
Bale, Tracy L. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (36) :9055-9065
[15]   The Stressed CNS: When Glucocorticoids Aggravate Inflammation [J].
Sorrells, Shawn F. ;
Caso, Javier R. ;
Munhoz, Carolina D. ;
Sapolsky, Robert M. .
NEURON, 2009, 64 (01) :33-39